Effects of low‐dust forages on dust exposure, airway cytology, and plasma omega‐3 concentrations in Thoroughbred racehorses: A randomized clinical trial

Autor: Carla J. Olave, Kathleen M. Ivester, Laurent L. Couetil, John Burgess, Jae Hong Park, Abhijit Mukhopadhyay
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Journal of Veterinary Internal Medicine, Vol 37, Iss 1, Pp 338-348 (2023)
Druh dokumentu: article
ISSN: 1939-1676
0891-6640
DOI: 10.1111/jvim.16598
Popis: Abstract Background Racehorses commonly develop evidence of mild asthma in response to dust exposure. Diets deficient in omega‐3 polyunsaturated fatty acids (Ω‐3) might exacerbate this response. Hypothesis To compare dust exposure, bronchoalveolar lavage fluid (BALF) cytology, and plasma Ω‐3 and specialized pro‐resolving mediators (SPM) concentrations amongst racehorses fed dry hay, steamed hay, and haylage. Animals Forty‐three Thoroughbred racehorses. Methods Prospective clinical trial. Horses were randomly assigned to be fed dry hay, steamed hay, or haylage for 6 weeks. Measures of exposure to dust in the breathing zone were obtained twice. At baseline, week‐3, and week‐6, BALF cytology was examined. Plasma lipid profiles and plasma SPM concentrations were examined at baseline and week 6. Generalized linear mixed models examined the effect of forage upon dust exposure, BALF cytology, Ω‐3, and SPM concentrations. Results Respirable dust was significantly higher for horses fed hay (least‐square mean ± s.e.m. 0.081 ± 0.007 mg/m3) when compared with steamed hay (0.056 ± 0.005 mg/m3, P = .01) or haylage (0.053 ± 0.005 mg/m3, P
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