Drug Development in Soft Tissue Sarcomas: Novel Targets and Recent Early Phase Trial Results

Autor:	Ella Achenbach, David Lai, Shiraj Sen
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	sarcoma drug development clinical trials Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Immunologic diseases. Allergy RC581-607
Zdroj:	Journal of Immunotherapy and Precision Oncology, Pp 83-89 (2020)
Druh dokumentu:	article
ISSN:	2666-2345 2590-017X
DOI:	10.36401/JIPO-20-4
Popis:	Soft tissue sarcomas are a heterogeneous group of rare malignancies with few effective standard therapies. Our understanding of the underlying biology driving tumorigenesis in these mesenchymal tumors have led to a growth in drug development for soft tissue sarcomas. This review focuses on novel targets in soft tissue sarcomas, describes early clinical trial results of drugs directed at these targets, and discusses the data surrounding the use of these compounds in clinical practice and rationale for possible future US Food and Drug Administration approvals.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/fd9a66686bd94bd4870f02b63082a2fb Zobrazit plný text záznamu View record in DOAJ