The synthesis of water-soluble CDM-AM copolymer by irradiation and its solubilization effect on hydrophobic drugs

Autor: Yong-Fu Li, Hong-Tao Tang, Si-Jing Zhou
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Designed Monomers and Polymers, Vol 21, Iss 1, Pp 105-115 (2018)
Druh dokumentu: article
ISSN: 1568-5551
15685551
DOI: 10.1080/15685551.2018.1480681
Popis: The β-cyclodextrin-acrylamide (CDM-AM) copolymer was prepared from acrylamide and β-CD maleate (CDM) using 60Co γ-ray irradiation method. The optimized preparation conditions for the CDM-AM copolymer are as follows: CDM:AM mass ratio of 1:1; irradiation dose of 4 kGy; and using 20 mL of DMF water solution. The yield rate of CDM-AM was 75% in grams using these synthetic conditions. The effects of the CDM-AM copolymer on the solubility and fungicidal activity of natamycin (NM) and carbendazim (MBC) were investigated. The stability constant of NM·CDM-AM and MBC·CDM-AM complexes at 303 K were of 13,446.06 M−1 and 2595.3 M−1, respectively. The complexes were characterized using phase solubility diagrams, NMR spectra and FT-IR spectra. The analysis of the biological activities of these two complexes indicated that they possessed enhancing fungicidal activities compared to NM and MBC alone.
Databáze: Directory of Open Access Journals
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