Prediction of plasma volume and total hemoglobin mass with machine learning

Autor: B. Moreillon, B. Krumm, J. J. Saugy, M. Saugy, F. Botrè, J. M. Vesin, R. Faiss
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Physiological Reports, Vol 11, Iss 19, Pp n/a-n/a (2023)
Druh dokumentu: article
ISSN: 2051-817X
DOI: 10.14814/phy2.15834
Popis: Abstract Hemoglobin concentration ([Hb]) is used for the clinical diagnosis of anemia, and in sports as a marker of blood doping. [Hb] is however subject to significant variations mainly due to shifts in plasma volume (PV). This study proposes a newly developed model able to accurately predict total hemoglobin mass (Hbmass) and PV from a single complete blood count (CBC) and anthropometric variables in healthy subject. Seven hundred and sixty‐nine CBC coupled to measures of Hbmass and PV using a CO‐rebreathing method were used with a machine learning tool to calculate an estimation model. The predictive model resulted in a root mean square error of 33.2 g and 35.6 g for Hbmass, and 179 mL and 244 mL for PV, in women and men, respectively. Measured and predicted data were significantly correlated (p
Databáze: Directory of Open Access Journals
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