Upregulation of miR-31* is negatively associated with recurrent/newly formed oral leukoplakia.
| Autor: | Wen Xiao, Zhe-Xuan Bao, Chen-Yang Zhang, Xiao-Yun Zhang, Lin-Jun Shi, Zeng-Tong Zhou, Wei-Wen Jiang |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | PLoS ONE, Vol 7, Iss 6, p e38648 (2012) |
| Druh dokumentu: | article |
| ISSN: | 1932-6203 91812984 |
| DOI: | 10.1371/journal.pone.0038648 |
| Popis: | BackgroundOral leukoplakia (OLK) is a potentially malignant disorder of the oral cavity. However, the underlying mechanism of OLK is still unclear. In this study, we explore possible miRNAs involved in OLK.Methodology/principal findingsUsing miRNA microarrays, we profiled miRNA expression in OLK and malignantly transformed OLK (mtOLK) tissue samples. The upregulation of miR-31*, miR-142-5p, miR-33a, miR-1259, miR-146b-5p, miR-886-3p, miR-886-5p, miR-519d, and miR-301a along with the downregulation of miR-572, miR-611, miR-602, miR-675, miR-585, miR-623, miR-637, and miR-1184 in mtOLK were new observations. Fluorescence in situ hybridization (FISH) analyses confirmed that miR-31* is highly expressed in mtOLK. There was a significant difference between the FISH score (pConclusions/significanceUpregulation of miR-31* is negatively associated with recurrent/newly formed OLK. MiR-31* may exert similar but distinguishable effects on biological function in oral cells with different malignant potential. FGF3 is the target of miR-31*. miR-31* may play an important role during OLK progression through regulating FGF3. MiRNA* strands may also have prominent roles in oral carcinogenesis. |
| Databáze: | Directory of Open Access Journals |
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