Molecular Recognition by Pillar[5]arenes: Evidence for Simultaneous Electrostatic and Hydrophobic Interactions

Autor:	Borja Gómez-González, Luis García-Río, Nuno Basílio, Juan C. Mejuto, Jesus Simal-Gandara
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	pillararene host:guest supramolecular hydrophobic ITC NMR Pharmacy and materia medica RS1-441
Zdroj:	Pharmaceutics, Vol 14, Iss 1, p 60 (2021)
Druh dokumentu:	article
ISSN:	1999-4923
DOI:	10.3390/pharmaceutics14010060
Popis:	The formation of inclusion complexes between alkylsulfonate guests and a cationic pillar[5]arene receptor in water was investigated by NMR and ITC techniques. The results show the formation of host-guest complexes stabilized by electrostatic interactions and hydrophobic effects with binding constants of up to 107 M−1 for the guest with higher hydrophobic character. Structurally, the alkyl chain of the guest is included in the hydrophobic aromatic cavity of the macrocycle while the sulfonate groups are held in the multicationic portal by ionic interactions.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/fd86c185e3ac4a9ab81c7c67fbfe4c8f Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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