| Autor: |
Twei-Shiun Jaw, Shih-Hsien Chen, Yun-Ming Wang, Jui-Sheng Hsu, Yu-Ting Kuo, Yen-Yu Chiu, Kun-Bow Tsai, Tsyh-Jyi Hsieh, Gin-Chung Liu |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
Kaohsiung Journal of Medical Sciences, Vol 28, Iss 3, Pp 130-137 (2012) |
| Druh dokumentu: |
article |
| ISSN: |
1607-551X |
| DOI: |
10.1016/j.kjms.2011.10.017 |
| Popis: |
To evaluate the competitive potential of a new lipophilic paramagnetic complex, Gd-Bz-TTDA [4-benzyl-3,6,10-tri (carboxymethyl)-3,6,10-triazado-decanedioic acid] compared with two other commercially available MR hepatobiliary contrast agents, gadobenate dimeglumine (Gd-BOPTA) and gadoxetic acid (Gd-EOB-DTPA), dynamic MR imaging studies were performed on normal and hepatocellular carcinoma (HCC) rat models using a 1.5-Tesla MR scanner. The results indicate that normal rats that were injected with 0.1 mmol/kg Gd-Bz-TTDA showed significantly more intense and persistent liver enhancement than those that were injected with the same dose of Gd-EOB-DTPA or Gd-BOPTA. All of these agents showed similar enhancement patterns in the implanted HCC. The liver-lesion contrast-to-noise ratios were higher and more persistent in rats that were injected with Gd-Bz-TTDA. These results indicate that Gd-Bz-TTDA is comparable with the commercially available hepatobiliary agents, Gd-EOB-DTPA and Gd-BOPTA, and can result in more intense and prolonged liver enhancement while still providing better liver-lesion discrimination. These results warrant further large-scale studies. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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