Synovial fluid neutrophil gelatinase-associated lipocalin can be used to accurately diagnose prosthetic joint infection

Autor: Zida Huang, Zijie Zhang, Mengqing Li, Wenbo Li, Xinyu Fang, Wenming Zhang
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: International Journal of Infectious Diseases, Vol 123, Iss , Pp 170-175 (2022)
Druh dokumentu: article
ISSN: 1201-9712
DOI: 10.1016/j.ijid.2022.08.009
Popis: Objectives: Neutrophil gelatinase-associated lipocalin (NGAL) in synovial fluid (SF) may have potential diagnostic value for prosthetic joint infection (PJI). This study aimed to study (i) the diagnostic performance of SF-NGAL levels for diagnosing PJI and (ii) the impact of previous antibiotic use on the SF-NGAL levels. Methods: Consecutive patients who needed hip or knee revision surgery were included prospectively from January 2017 to September 2018. The patients were divided into the PJI group and the aseptic failure group. An enzyme-linked immunosorbent assay was used to determine the SF-NGAL level. Results: A total of 50 of 78 included patients were diagnosed with PJI. The median SF-NGAL level was 3633 ng/ml (interquartile range [IQR], 1332-10,737) in the PJI group and 26.8 ng/ml (IQR, 12.4-52.5) in the aseptic failure group (P
Databáze: Directory of Open Access Journals