Duloxetine hydrochloride induced syndrome of inappropriate antidiuretic hormone secretion in depression treatment: a case report

Autor: Yang Shuting, Fan Ajiao
Jazyk: čínština
Rok vydání: 2024
Předmět:
Zdroj: Sichuan jingshen weisheng, Vol 37, Iss 4, Pp 376-378 (2024)
Druh dokumentu: article
ISSN: 1007-3256
DOI: 10.11886/scjsws20240229002
Popis: Duloxetine hydrochloride,a serotonin-norepinephrine reuptake inhibitor (SNRIs), is a commonly used antidepressants. Its mechanism of action involves increasing synaptic monoamine neurotransmitters concentration, leading to antidepressant effects. While gastrointestinal reactions and elevated blood pressure are common side effects, duloxetine can rarely induce syndrome of inappropriate antidiuretic hormone secretion (SIADH). This case report presents a patient with depression who developed SIADH following duloxetine hydrochloride initiation, with the main clinical manifestation being restless thirst and excessive drinking. This case is presented to raise awareness among clinicians of this rare yet potentially serious adverse effect of duloxetine treatment.
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