| Autor: |
Chia-Feng Liu, PhD, W.H. Wilson Tang, MD |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
JACC: Basic to Translational Science, Vol 4, Iss 8, Pp 976-993 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2452-302X |
| DOI: |
10.1016/j.jacbts.2019.05.011 |
| Popis: |
Summary: Heart failure (HF) is a complex syndrome affecting millions of people around the world. Over the past decade, the therapeutic potential of targeting epigenetic regulators in HF has been discussed extensively. Recent advances in next-generation sequencing techniques have contributed substantial progress in our understanding of the role of DNA methylation, post-translational modifications of histones, adenosine triphosphate (ATP)-dependent chromatin conformation and remodeling, and non-coding RNAs in HF pathophysiology. In this review, we summarize epigenomic studies on human and animal models in HF. Key Words: cardiac hypertrophy, epigenetics, heart failure |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
