| Autor: |
C. Loeuillet, B. Touquet, B. Oury, N. Eddaikra, J.L. Pons, J.F. Guichou, G. Labesse, D. Sereno |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 1, Pp 59-66 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
2211-3207 |
| DOI: |
10.1016/j.ijpddr.2018.01.002 |
| Popis: |
A series of aminophenylhydroxamates and aminobenzylhydroxamates were synthesized and screened for their antiparasitic activity against Leishmania, Trypanosoma, and Toxoplasma. Their anti-histone deacetylase (HDAC) potency was determined. Moderate to no antileishmanial or antitrypanosomal activity was found (IC50 > 10 μM) that contrast with the highly efficient anti-Toxoplasma activity (IC50 |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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