Photocatalytic Enantioselective Radical Cascade Multicomponent Minisci Reaction of β‐Carbolines Using Diazo Compounds as Radical Precursors

Autor:	Yi‐Jie Gu, Mu‐Peng Luo, Hua Yuan, Guo‐Kai Liu, Shou‐Guo Wang
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	asymmetric photocatalysis diazo compounds Minisci reaction multicomponent reaction radical cascade Science
Zdroj:	Advanced Science, Vol 11, Iss 25, Pp n/a-n/a (2024)
Druh dokumentu:	article
ISSN:	2198-3844
DOI:	10.1002/advs.202402272
Popis:	Abstract Here, a photocatalytic asymmetric multicomponent cascade Minisci reaction of β‐carbolines with enamides and diazo compounds is reported, enabling an effective enantioselective radical C─H functionalization of β‐carbolines with high yields and enantioselectivity (up to 83% yield and 95% ee). This enantioselective multicomponent Minisci protocol exhibits step economy, high chemo‐/enantio‐selective control, and good functional group tolerance, allowing access to a variety of valuable chiral β‐carbolines. Notably, diazo compounds are suitable radical precursors in enantioselective cascade radical reactions. Moreover, the efficiency and practicality of this approach are demonstrated by the asymmetric synthesis of bioactive compounds and natural products.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/cfd639dccd07468fbfd091ef3b40b7af Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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