Nephroblastoma Arising from Primary Testicular Germ Cell Tumor: A Case Report and Literature Review
| Autor: | Houda Alatassi, Brittany E. O’Bryan, Jamie C. Messer, Zhenglong Wang |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Case Reports in Pathology, Vol 2016 (2016) |
| Druh dokumentu: | article |
| ISSN: | 2090-6781 2090-679X |
| DOI: | 10.1155/2016/7318672 |
| Popis: | Adult extrarenal nephroblastoma is a very rare tumor. Nephroblastoma arising from primary testicular germ cell tumor is exceedingly rare. To our knowledge, only three cases have been reported in the English literature. We report a case of a 19-year-old man who presented with a large right testicle. Image studies showed a large retroperitoneal mass along with liver and lung metastases. Orchiectomy demonstrated a mixed germ cell tumor composed of yolk sac tumor, embryonal carcinoma, and mature and immature teratoma with a significant portion of nephroblastoma. The patient received chemotherapy and no recurrence was noted during six months of followup. WT-1 expression was also studied due to the lack of consistency of its expression in testicular nephroblastoma in the literature. We also present a discussion and review of the literature due to its rarity, which indicate an adverse prognosis for patients with nephroblastoma components receiving standard chemotherapeutical regimes for testicular germ cell tumors. |
| Databáze: | Directory of Open Access Journals |
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