Mucormycosis in children with hematological malignancies: results of a single-center study
| Autor: | Solopova G.G., Myakova N.V., Shelikhova L.N., Litvinov D.V., Grachev N.S., Talypov S.R., Hamin I.G., Konovalov D.M., Maschan A.A., Novichkova G.A. |
|---|---|
| Jazyk: | ruština |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Клиническая микробиология и антимикробная химиотерапия, Vol 21, Iss 1, Pp 39-45 (2019) |
| Druh dokumentu: | article |
| ISSN: | 1684-4386 2686-9586 45258058 |
| DOI: | 10.36488/cmac.2019.1.39-45 |
| Popis: | Objective. To assess the incidence rate, risk factors and treatment outcomes of mucormycosis in children with hematological malignancies in the large tertiary hematology/oncology center. Materials and Methods. A total of 16 children (9 males/7 females) with mucormycosis were enrolled in a single-center, retrospective study over the period of 2012–2018. All patients had an underlying diagnosis of acute leukemia. Mucormycosis was diagnosed at the different timepoints after chemotherapy (CT) or hematopoietic stem cell transplantation (HSCT) in 15 cases and before CT in 1 case. The diagnosis of mucormycosis was based on clinical, microbiological or histological results. The median patient’s age at the time of mucormycosis diagnosis was 7.7 years. Results. The average incidence of mucormycosis was 1.15%, while in 2018 the overall incidence was significantly increased to 4% (p = 0.039), primarily due to patients with acute myeloid leukemia (9.75%, р = 0.004). The main risk factors were prolonged neutropenia (median – 30 days) |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|