Comparative efficacy of image-guided techniques in cardiac resynchronization therapy: a meta-analysis

Autor: Xiao Hu, Hai Xu, Shameer Raaj Avishkar Hassea, Zhiyong Qian, Yao Wang, Xinwei Zhang, Xiaofeng Hou, Jiangang Zou
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: BMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-13 (2021)
Druh dokumentu: article
ISSN: 1471-2261
DOI: 10.1186/s12872-021-02061-y
Popis: Abstract Background Several studies have illustrated the use of echocardiography, magnetic resonance imaging, and nuclear imaging to optimize left ventricular (LV) lead placement to enhance the response of cardiac resynchronization therapy (CRT) in heart failure patients. We aimed to conduct a meta-analysis to determine the incremental efficacy of image-guided CRT over standard CRT. Methods We searched PubMed, Cochrane library, and EMBASE to identify relevant studies. The outcome measures of cardiac function and clinical outcomes were CRT response, concordance of the LV lead to the latest sites of contraction (concordance of LV), heart failure (HF) hospitalization, mortality rates, changes of left ventricular ejection fraction (LVEF), and left ventricular end-systolic volume (LVESV). Results The study population comprised 1075 patients from eight studies. 544 patients underwent image-guided CRT implantation and 531 underwent routine implantation without imaging guidance. The image-guided group had a significantly higher CRT response and more on-target LV lead placement than the control group (RR, 1.33 [95% CI, 1.21 to 1.47]; p
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