Comparison of Iridium(I) Catalysts in Temperature Mediated Hydrogen Isotope Exchange Reactions

Autor:	Mégane Valero, Dr. Anurag Mishra, Jennifer Blass, Remo Weck, Dr. Volker Derdau
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	hydrogen isotope exchange deuterium iridium catalysis C−H functionalization homogeneous catalysis Chemistry QD1-999
Zdroj:	ChemistryOpen, Vol 8, Iss 9, Pp 1183-1189 (2019)
Druh dokumentu:	article
ISSN:	2191-1363
DOI:	10.1002/open.201900204
Popis:	Abstract The reactivity and selectivity of iridium(I) catalysed hydrogen isotope exchange (HIE) reactions can be varied by using wide range of reaction temperatures. Herein, we have done a detailed comparison study with common iridium(I) catalysts (1–6) which will help us to understand and optimize the approaches of either high selectivity or maximum deuterium incorporation. We have demonstrated that the temperature window for these studied iridium(I) catalysts is surprisingly very broad. This principle was further proven in some HIE reactions on complex drug molecules.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/fd45a41c3a814e2fa5d3bd8e67631e5d Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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