Synthesis of BODIPY FL-tethered ridaifen-B, RID-B-BODIPY, and its localization in cancer cells

Autor: Takatsugu Murata, Kyoka Komukai, Yuta Semba, Eri Murata, Fumi Sato, Tomohiro Takano, Kaho Tsuchiya, Chihiro Matsuda, Anju Sakai, Amane Yoneoka, Shunsuke Takahashi, Yukitoshi Nagahara, Isamu Shiina
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Frontiers in Chemistry, Vol 12 (2024)
Druh dokumentu: article
ISSN: 2296-2646
DOI: 10.3389/fchem.2024.1451468
Popis: We synthesized ridaifen-B boron dipyrromethene (RID-B-BODIPY) using 2-methyl-6-nitro benzoic anhydride (MNBA)-mediated dehydration condensation reaction between amino alkyl-tethered RID and BODIPY FL. Comparative experiments between dicyclohexylcarbodiimide (DCC) and MNBA for their coupling reactions demonstrated that MNBA is an effective condensation reagent for amines and BODIPY FL. A cell staining study with RID-B-BODIPY showed intracellular localization of BODIPY FL fluorescence, attributed to the RID-B structure, indicating the successful development of a tool for analyzing intracellular molecular behavior efficiently.
Databáze: Directory of Open Access Journals
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