ARID1A mutation and genomic stability
| Autor: | Timothy Nacarelli, Bo Zhao, Xue Hao, Rugang Zhang |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Molecular & Cellular Oncology, Vol 7, Iss 3 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2372-3556 23723556 24253642 |
| DOI: | 10.1080/23723556.2019.1690923 |
| Popis: | We have recently discovered that AT-rich interactive domain-containing protein 1A (ARID1A) protects telomere cohesion through regulation of the cohesin subunit stromal antigen 1 (STAG1). ARID1A inactivation results in mitotic defects and negatively selects gross chromosomal aberrations, resulting in preservation of genomic stability in ARID1A-mutated cancers. These findings explain the long-standing paradox between mitotic defects caused by ARID1A inactivation and the lack of genomic instability in ARID1A-mutated cancers. |
| Databáze: | Directory of Open Access Journals |
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