| Autor: |
Kay Palopoli-Trojani, Stephen L. Schmidt, Karley D. Baringer, Theodore A. Slotkin, Jennifer J. Peters, Dennis A. Turner, Warren M. Grill |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Brain Stimulation, Vol 16, Iss 6, Pp 1630-1642 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1935-861X |
| DOI: |
10.1016/j.brs.2023.10.009 |
| Popis: |
Background: Traditional deep brain stimulation (DBS) at fixed regular frequencies (>100 Hz) is effective in treating motor symptoms of Parkinson's disease (PD). Temporally non-regular patterns of DBS are a new parameter space that may help increase efficacy and efficiency. Objective: To compare the effects of temporally non-regular patterns of DBS to traditional regularly-spaced pulses. Methods: We simultaneously recorded local field potentials (LFP) and monitored motor symptoms (tremor and bradykinesia) in persons with PD during DBS in subthalamic nucleus (STN). We quantified both oscillatory activity and DBS local evoked potentials (DLEPs) from the LFP. Results: Temporally non-regular patterns were as effective as traditional pulse patterns in modulating motor symptoms, oscillatory activity, and DLEPs. Moreover, one of our novel patterns enabled recording of longer duration DLEPs during clinically effective stimulation. Conclusions: Stimulation gaps of 50 ms can be used to increase efficiency and to enable regular assessment of long-duration DLEPs while maintaining effective symptom management. This may be a promising paradigm for closed-loop DBS with biomarker assessment during the gaps. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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