False positive results: a challenge for laboratory physicians and hematologists in treating multiple myeloma with daratumumab

Autor:	Shanshan Liang, Weihua Feng, Hongbing Ma, Li Zhang, Chengyao Jia
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Multiple myeloma daratumumab serum protein electrophoresis immunofixation Diseases of the blood and blood-forming organs RC633-647.5
Zdroj:	Hematology, Vol 27, Iss 1, Pp 332-336 (2022)
Druh dokumentu:	article
ISSN:	16078454 1607-8454
DOI:	10.1080/16078454.2022.2045723
Popis:	Daratumumab injection was approved by China in 2019 for the treatment of recurrent or refractory multiple myeloma. However, the molecular weight of daratumumab, an immunoglobin G1 kappa human monoclonal antibody, was similar to that of M protein and could not be distinguished from IgG κ M protein in SPEP and SIFE. It might lead to false-positive detection resulting in misdiagnose and confusing evaluation of therapeutic response, especially for patients with IgG κ M proteins. Herein, we reported two cases encountered in our daily clinical work. These two case reports could serve as a reminder to global hematologists who have not yet started or just begun to use the drug of daratumumab.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/fd2632ea618c450a8d73e328846171e3 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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