| Autor: |
Abdelkader Chalghoum, Yosri Noichri, Ines Karkouch, Azza Dandana, Bruno Baudin, Guieder Jeridi, Salima Ferchichi, Abdelhédi Miled |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
Biological Research, Vol 48, Iss 0, Pp 1-6 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
0716-9760 |
| DOI: |
10.1186/S40659-015-0018-7 |
| Popis: |
BACKGROUND: Acute coronary syndromes (ACS) are complex and polygenic diseases which are a real problem of public health. These syndromes require multidisciplinary studies to understand the pathogenesis mechanisms and metabolic interactions between different risk factors.This study aimed to explore the variation of two coronary risk parameters not mentioned by Framingham cohorts, hyperhomocysteinemia and endothelin-1 (ET-1) in Tunisian coronary and the study of the variation of these parameters based on various cardiac risk factors and metabolic relationship between them.To 157 coronary and 142 healthy subjects, the concentration of homocysteine was quantified by fluorescence polarization immunoassay; the concentration of ET-1 was measured by an analytical technique, the High Performance Liquid Chromatography (HPLC) coupled with mass spectrometry. RESULTS: Our study showed that homocysteine and ET-1 were significantly higher in patients compared to healthy subjects (24.40 ± 12.5 μmol/L vs 7.44 ± 2.5 μmol/L p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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