Potent anti-tumor immunostimulatory biocompatible nanohydrogel made from DNA

Autor: Jiana Jiang, Xianming Kong, Yuexia Xie, Hanbing Zou, Qianyun Tang, Ding Ma, Xue Zhao, Xiaozhen He, Anyue Xia, Peifeng Liu
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Nanoscale Research Letters, Vol 14, Iss 1, Pp 1-10 (2019)
Druh dokumentu: article
ISSN: 1931-7573
1556-276X
DOI: 10.1186/s11671-019-3032-9
Popis: Abstract Unmethylated CpG oligodeoxynucleotides are potent immunostimulatory motifs in activating both innate and acquired immune system by inducing Th1 type antigen-specific T cell responses, but their instability in serum greatly influences their immunostimulant efficiency. Here, we constructed a novel immuno-DNA nanohydrogels consisting of tandem repeat sequences of CpG units named CpG-MCA nanohydrogels through multi-primed chain amplification. CpG-MCA nanohydrogels were proved to resist degradation and increase the proliferation and migration of murine macrophage-like RAW264.7 cells. Furthermore, CpG-MCA nanohydrogels effectively induced high expression of tumor necrosis factor-α and interleukin-6, and remarkably inhibited the proliferation of U251 cells, suggesting that CpG-MCA nanohydrogels are expected to be employed as the potent anti-cancer immunostimulant.
Databáze: Directory of Open Access Journals
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