Renal function evaluation in patients with American Cutaneous Leishmaniasis after specific treatment with pentavalent antimonial

Autor: Oliveira Rodrigo A, Lima Cláudio G, Mota Rosa, Martins Alice, Sanches Talita R, Seguro Antônio C, Andrade Lúcia C, Junior Geraldo, Libório Alexandre B, Daher Elizabeth F
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Zdroj: BMC Nephrology, Vol 13, Iss 1, p 44 (2012)
Druh dokumentu: article
ISSN: 1471-2369
DOI: 10.1186/1471-2369-13-44
Popis: Abstract Background Renal evaluation studies are rare in American Cutaneous Leishmaniasis (ACL). The aim of this study is to investigate whether specific treatment reverts ACL-associated renal dysfunction. Methods A prospective study was conducted with 37 patients with ACL. Urinary concentrating and acidification ability was assessed before and after treatment with pentavalent antimonial. Results The patients mean age was 35.6 ± 12 years and 19 were male. Before treatment, urinary concentrating defect (U/Posm Conclusion As previously described, urinary concentrating and acidification defects were found in an important number of patients with ACL. Present results demonstrate that only some patients recover urinary acidification capacity, while no one returned to normal urinary concentration capacity.
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