| Autor: |
Javeed Iqbal Bhat, Hilal Ahmad Rather, Ambreen Ali Ahangar, Umar Amin Qureshi, Parvez Dar, Qazi Iqbal Ahmed, Bashir Ahmed Charoo, Syed Wajid Ali |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Indian Heart Journal, Vol 69, Iss 1, Pp 24-27 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
0019-4832 |
| DOI: |
10.1016/j.ihj.2016.07.015 |
| Popis: |
Objective: To study the effect of thiamine administration on the resolution of pulmonary hypertension in exclusively breastfed infants. Design: Prospective cohort study. Setting: Hospital based study of a tertiary care hospital. Patients: A total of 29 infants with 17 males (58.6%) and 12 females (41.4%) were included in the study. Intervention: In addition to the management of shock, right heart failure and renal failure, patients received intravenous thiamine 100 mg/kg IV followed by 10 mg/day till introduction of supplementary feeds. Main outcomes measures: Resolution of shock, metabolic complications and pulmonary hypertension. Results: Mean age at presentation was 78.45 ± 30.7 days. All infants were exclusively breastfed. 86.2% of mothers were on customary dietary restrictions. Biventricular failure and tachycardia was commonly present. There were four deaths in our series. Acute metabolic acidosis was a universal feature with a mean pH of 7.21 ± 0.15. Pulmonary hypertension was present in all patients on admission. Intravenous thiamine 100 mg/kg IV stat was given immediately after documenting pulmonary hypertension. Repeat echocardiography showed complete resolution of pulmonary hypertension. Conclusion: Many infants present to us with Shoshin beriberi with unusually high pulmonary pressures. These patients respond to thiamine challenge with prompt resolution of metabolic complications and reversal of pulmonary hypertension. We believe this is first of its kind from the region, which is reported. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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