| Autor: |
Coline Plé, Nadège Adouard, Jérôme Breton, Joëlle Dewulf, Bruno Pot, Pascal Bonnarme, Benoit Foligné |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
Journal of Functional Foods, Vol 12, Iss , Pp 219-229 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2014.11.021 |
| Popis: |
Although large numbers of viable microorganisms are ingested in ripened cheese, little is known about the microbial ecosystems' influence on the host's immune responses. We designed experimental smear-ripened cheeses with bacteria and yeasts that have opposite immune effects and evaluated their impact in the dextran sulphate sodium (DSS) and trinitrobenzene sulphonic acid (TNBS) colitis mouse models. Mice were fed with a control diet, a milk matrix or with lab-designed, 28-day-ripened prototype soft cheeses A and B (CheA and CheB) from cow milk that respectively hosted consortia of immuno-enhancing and immuno-modulatory microbial strains. Inflammatory markers and transcriptional signatures were evaluated in healthy mice colitic mice. In the DSS colitis model, there were no differences between CheA and CheB in terms of the inflammatory read-outs. In contrast, CheA (but not CheB) exacerbated weight loss and colon lesions in the TNBS model suggesting that designer cheeses may provide opportunities for diet management. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect