Prevalence and risk factors for impaired glucose regulation among first-degree relatives of patients with type 2 diabetes mellitus in Maiduguri, Northeastern Nigeria

Autor: Haliru Ibrahim, Fabian H Puepet, Salisu B Muazu, Bilkisu M Mubi, Ibrahim D Gezawa, Shettima K Mustapha, Bukar Bakki, Abdullahi M Talle, Godspower C Michael, Ibrahim Aliyu
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Journal of Diabetology, Vol 11, Iss 1, Pp 25-31 (2020)
Druh dokumentu: article
ISSN: 2078-7685
DOI: 10.4103/jod.jod_5_19
Popis: Background/Purpose: Owing to genetic predilection of type 2 diabetes mellitus (T2DM), the risk of developing impaired glucose metabolism is thought to be higher in first-degree relatives (FDRs) of those with T2DM. The aim of this study was to estimate the prevalence of impaired glucose tolerance (IGT) and impaired fasting glycemia (IFG) and its associated risk factors in FDRs of patients with T2DM. Materials and Methods: This is a cross-sectional descriptive study of 320 cases (FDRs of T2DM outpatients) aged ≥25 years (145 males and 175 females) and 160 controls (76 males, 84 females) who were age and sex matched. All subjects underwent anthropometric, physical activity, and laboratory assessments after an overnight fast. Oral glucose tolerance test with 75g anhydrous glucose was administered. Fasting plasma glucose of 6.1–6.9 mmol/L and 2-h post-fasting glucose value of 7.8–11.0 mmol/L were used to define IFG and IGT, respectively. Statistical analysis was carried out using the Statistical Package for the Social Sciences software, version 20 (SPSS, Chicago, Illinois), and P value of
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