| Autor: |
Nicola Veronese, Francesco Di Gennaro, Luisa Frallonardo, Stefano Ciriminna, Roberta Papagni, Luca Carruba, Diletta Agnello, Giuseppina De Iaco, Nicolò De Gennaro, Giuseppina Di Franco, Liliana Naro, Gaetano Brindicci, Angelo Rizzo, Davide Fiore Bavaro, Maria Chiara Garlisi, Carmen Rita Santoro, Fabio Signorile, Flavia Balena, Pasquale Mansueto, Eugenio Milano, Lydia Giannitrapani, Deborah Fiordelisi, Michele Fabiano Mariani, Andrea Procopio, Rossana Lattanzio, Anna Licata, Laura Vernuccio, Simona Amodeo, Giacomo Guido, Francesco Vladimiro Segala, Mario Barbagallo, Annalisa Saracino |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Scientific Reports, Vol 14, Iss 1, Pp 1-7 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-024-59957-w |
| Popis: |
Abstract Remdesivir (RDV) was the first Food and Drug Administration (FDA)-approved medication for COVID-19, with discordant data on efficacy in reducing mortality risk and disease progression. In the context of a dynamic and rapidly changing pandemic landscape, the utilization of real-world evidence is of utmost importance. The objective of this study is to evaluate the impact of RDV on patients who have been admitted to two university referral hospitals in Italy due to COVID-19. All patients older than 18 years and hospitalized at two different universities (Bari and Palermo) were enrolled in this study. To minimize the effect of potential confounders, we used propensity score matching with one case (Remdesivir) and one control that never experienced this kind of intervention during hospitalization. Mortality was the primary outcome of our investigation, and it was recorded using death certificates and/or medical records. Severe COVID-19 was defined as admission to the intensive care unit or a qSOFAscore ≥ 2 or CURB65scores ≥ 3. After using propensity score matching, 365 patients taking Remdesivir and 365 controls were included. No significant differences emerged between the two groups in terms of mean age and percentage of females, while patients taking Remdesivir were less frequently active smokers (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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