EMERGING USE OF JANUS KINASE INHIBITORS FOR ORAL LICHEN PLANUS
| Autor: | Mihaela Paula Toader, Daciana Elena Branisteanu, Oana Mihaela Condurache Hritcu, Cristina Popa, Ana Maria Sciuca, Bianca Andreea Onofrei, Stefan Vasile Toader |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Romanian Journal of Oral Rehabilitation, Vol 16, Iss 2, Pp 527-532 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2066-7000 2601-4661 |
| DOI: | 10.6261/RJOR.2024.2.16.48 |
| Popis: | Oral lichen planus (OLP) is a chronic inflammatory condition that poses significant therapeutic challenges. Emerging evidence suggests that topical Janus Kinase (JAK) inhibitors could represent a novel treatment paradigm for OLP. This review explores the pathophysiology of OLP, highlighting the role of the JAK-STAT pathway in its pathogenesis. We discuss the current landscape of topical JAK inhibitors, including their mechanism of action, efficacy, and safety profile. The review also examines recent clinical trials and observational studies that shed light on the potential of these agents in managing OLP. Finally, we provide a perspective on the future of JAK inhibitors in the context of OLP treatment, considering both their therapeutic potential and the need for further research. |
| Databáze: | Directory of Open Access Journals |
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