SARS-CoV-2 early infection signature identified potential key infection mechanisms and drug targets

Autor:	Yue Li, Ashley Duche, Michael R. Sayer, Don Roosan, Farid G. Khalafalla, Rennolds S. Ostrom, Jennifer Totonchy, Moom R. Roosan
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	COVID-19 SARS-CoV-2 gene expression signature Bronchoalveolar lavage fluid cells Peripheral blood mononuclear cells COVID-19 treatments Biotechnology TP248.13-248.65 Genetics QH426-470
Zdroj:	BMC Genomics, Vol 22, Iss 1, Pp 1-13 (2021)
Druh dokumentu:	article
ISSN:	1471-2164
DOI:	10.1186/s12864-021-07433-4
Popis:	Abstract Background The ongoing COVID-19 outbreak has caused devastating mortality and posed a significant threat to public health worldwide. Despite the severity of this illness and 2.3 million worldwide deaths, the disease mechanism is mostly unknown. Previous studies that characterized differential gene expression due to SARS-CoV-2 infection lacked robust validation. Although vaccines are now available, effective treatment options are still out of reach. Results To characterize the transcriptional activity of SARS-CoV-2 infection, a gene signature consisting of 25 genes was generated using a publicly available RNA-Sequencing (RNA-Seq) dataset of cultured cells infected with SARS-CoV-2. The signature estimated infection level accurately in bronchoalveolar lavage fluid (BALF) cells and peripheral blood mononuclear cells (PBMCs) from healthy and infected patients (mean 0.001 vs. 0.958; P
Databáze:	Directory of Open Access Journals
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