Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease
| Autor: | Sarah Gooding, Sam W. Z. Olechnowicz, Emma V. Morris, Andrew E. Armitage, Joao Arezes, Joe Frost, Emmanouela Repapi, James R. Edwards, Neil Ashley, Craig Waugh, Nicola Gray, Erik Martinez-Hackert, Pei Jin Lim, Sant-Rayn Pasricha, Helen Knowles, Adam J. Mead, Karthik Ramasamy, Hal Drakesmith, Claire M. Edwards |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
| Druh dokumentu: | article |
| ISSN: | 2041-1723 87742128 |
| DOI: | 10.1038/s41467-019-12296-1 |
| Popis: | Multiple myeloma is a cancer of the bone marrow that can induce bone disease. Here, the authors profile the transcriptome of bone-lining cells and find a targetable role of bone morphogenetic protein (BMP) signalling in myeloma-induced bone-disease |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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