UPF1 promotes the formation of R loops to stimulate DNA double-strand break repair
| Autor: | Greg H. P. Ngo, Julia W. Grimstead, Duncan M. Baird |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2041-1723 33037469 |
| DOI: | 10.1038/s41467-021-24201-w |
| Popis: | R loops are formed when single-stranded RNA anneals to one strand of DNA, forming three-stranded structures containing DNA-RNA hybrids and the displaced non-template single-stranded DNA. Here the authors reveal that the DNA:RNA helicase UPF1 plays a role in promoting R loops formation at telomeric double strand breaks to stimulate DNA resection and repair. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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