| Autor: |
Le Zhou, Li-Li Lou, Wei Wang, Bin Lin, Jun-Ning Chen, Xiao-Bo Wang, Xiao-Xiao Huang, Shao-Jiang Song |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Journal of Functional Foods, Vol 37, Iss , Pp 322-329 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2017.08.007 |
| Popis: |
Red raspberry (Rubus idaeus L.) is an edible fruit-producing species belonging to the Rosaceae family. In our search for potential agents for treating Alzheimer’s disease in this functional food, we decided to investigate the chemical constituents of red raspberry. Four pairs of enantiomeric 8-O-4′-type neolignans (1a/1b–4a/4b), including three new compounds (1a/1b and 2a), were identified from the fruit of red raspberry. Their chemical structures were determined by spectroscopic data analyses, and all these isolated compounds were evaluated for their inhibition of self-induced Aβ aggregation, and 1b, 2a and 2b exhibited significant Aβ aggregation inhibition ability. The results of the docking study of enantiomeric compounds 1a/1b and 3a/3b were consistent with the results of the thioflavin-T assay, and were used to further interpret the effects of a variety of stereochemical configurations on the Aβ aggregation assay. Moreover, their neuroprotective activities were also evaluated. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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