Risk factor analysis and molecular epidemiology of respiratory adenovirus infections among children in northern Taiwan, 2009–2013

Autor: Jia Lu Cheng, Chun-Chih Peng, Nan-Chang Chiu, Li-Chuan Weng, Yu-Ying Chiu, Lung Chang, Daniel Tsung-Ning Huang, Fu-Yuan Huang, Chang-Pan Liu, Hsin Chi
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Journal of Microbiology, Immunology and Infection, Vol 50, Iss 4, Pp 418-426 (2017)
Druh dokumentu: article
ISSN: 1684-1182
DOI: 10.1016/j.jmii.2015.08.006
Popis: Background/Purpose: Respiratory infections caused by human adenoviruses (HAdV) are worldwide, and have significantly increased recently in Taiwan. This study aimed to clarify the molecular epidemiology and risk factors of HAdV severe infections and pneumonia among Taiwanese children. Methods: Patients with HAdV infections and hospitalized in a medical center between 2009 and 2013 were divided into severe or nonsevere HAdV infections based on whether or not they received intensive care. HAdV pneumonia was identified for comparison. The HAdV genotype was determined by sequencing the partial hexon and fiber genes. The nucleotide sequences were compared by phylogenetic analysis. Results: The 176 patients (97 boys, 79 girls) had a median age of 3.7 years. The HAdV infections circulated year-round. HAdV B3 (54.5%) was the most common genotype, followed by HAdV C2 (21%), HAdV E4 (8%), and HAdV B7 (6.8%). Thirty-two patients needed intensive care. In multivariate analysis, the risk factors for severe HAdV infections were underlying neurologic diseases [odds ratio (OR): 164.9; p
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