Gaps and Future Directions in Clinical Research on Obesity-Related Asthma

Autor:	Andi C. Hudler, Isaías Raymundo Ramírez Díaz, Sunita Sharma, Fernando Holguin
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Asthma Obesity Airway inflammation Metabolic dysregulation Diseases of the respiratory system RC705-779
Zdroj:	Pulmonary Therapy, Vol 9, Iss 3, Pp 309-327 (2023)
Druh dokumentu:	article
ISSN:	2364-1754 2364-1746
DOI:	10.1007/s41030-023-00230-2
Popis:	Abstract Obesity is a major comorbidity for the development and worsening of asthma. It is associated with increased disease incidence, reduced response to inhaled and systemic steroids, increased asthma exacerbations, and poor disease control. Over the past two decades, we have learned that there are clinical asthma phenotypes associated with obesity, which have unique immune, inflammatory, and metabolic disease mechanisms. The objectives of this review are to provide a brief overview of the associations and gaps between these chronic inflammatory diseases and the role that traditional therapies have on treating patients with obesity-related asthma, and to describe new clinical research of therapeutic developments targeting mechanisms that are more specific to this patient population.
Databáze:	Directory of Open Access Journals
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