Associations of the triglyceride-glucose index and remnant cholesterol with coronary artery disease: a retrospective study

Autor: Xiaosheng Wu, Weiping Qiu, Houlin He, Guojun Zhao, Jianling Liu
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Lipids in Health and Disease, Vol 23, Iss 1, Pp 1-8 (2024)
Druh dokumentu: article
ISSN: 1476-511X
DOI: 10.1186/s12944-024-02036-w
Popis: Abstract Background Remnant cholesterol (RC) represents a low-cost and readily measured lipid index that contributes significantly to residual cardiovascular disease risk. The triglyceride-glucose (TyG) index exhibits a significant correlation with cardiovascular disease occurrence. However, RC and the TyG index have rarely been examined for their potentials in predicting coronary artery disease (CAD). Accordingly, the study was designed to validate the correlations of these two biomarkers with CAD and to compare the forecasted values of these two biomarkers for newly diagnosed CAD. Methods Totally 570 subjects firstly administered coronary angiography were enrolled, including 431 newly diagnosed CAD cases and 139 individuals without CAD. The individuals were classified into two groups according to CAD diagnosis. RC was derived as total cholesterol content (mmol/L) – (high density lipoprotein cholesterol content + low density lipoprotein cholesterol content; both in mmol/L). The TyG index was determined as ln (fasting triglyceride level [mg/dL] × fasting plasma glucose level [mg/dL])/2. Results Baseline feature analysis revealed significant differences in RC and the TyG index between the CAD and non-CAD groups (both P
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