Prediction of TP53 mutations by p53 immunohistochemistry and their prognostic significance in gastric cancer
| Autor: | Hye Jung Hwang, Soo Kyung Nam, Hyunjin Park, Yujun Park, Jiwon Koh, Hee Young Na, Yoonjin Kwak, Woo Ho Kim, Hye Seung Lee |
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| Jazyk: | English<br />Korean |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Journal of Pathology and Translational Medicine, Vol 54, Iss 5, Pp 378-386 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2383-7837 2383-7845 |
| DOI: | 10.4132/jptm.2020.06.01 |
| Popis: | Background Recently, molecular classifications of gastric cancer (GC) have been proposed that include TP53 mutations and their functional activity. We aimed to demonstrate the correlation between p53 immunohistochemistry (IHC) and TP53 mutations as well as their clinicopathological significance in GC. Methods Deep targeted sequencing was performed using surgical or biopsy specimens from 120 patients with GC. IHC for p53 was performed and interpreted as strong, weak, or negative expression. In 18 cases (15.0%) with discrepant TP53 mutation and p53 IHC results, p53 IHC was repeated. Results Strong expression of p53 was associated with TP53 missense mutations, negative expression with other types of mutations, and weak expression with wild-type TP53 (p |
| Databáze: | Directory of Open Access Journals |
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