HLA-G 14 bp Ins/Del (rs66554220) Variant Is Not Associated with Breast Cancer in Women from Western Mexico

Autor: Denisse Stephania Becerra-Loaiza, Luisa Fernanda Roldan Flores, Luis Antonio Ochoa-Ramírez, Bricia M. Gutiérrez-Zepeda, Alicia Del Toro-Arreola, Ramón Antonio Franco-Topete, Andrés Morán-Mendoza, Antonio Oceguera-Villanueva, Antonio Topete, David Javalera, Antonio Quintero-Ramos, Adrián Daneri-Navarro
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Current Issues in Molecular Biology, Vol 45, Iss 8, Pp 6842-6850 (2023)
Druh dokumentu: article
ISSN: 1467-3045
1467-3037
DOI: 10.3390/cimb45080432
Popis: HLA-G is a physiology and pathologic immunomodulator detrimentally related to cancer. Its gene is heavily transcriptionally and post-transcriptionally regulated by variants located in regulator regions like 3′UTR, being the most studied Ins/Del of 14-bp (rs66554220), which is known to influence the effects of endogen cell factors; nevertheless, the reports are discrepant and controversial. Herein, the relationship of the 14-bp Ins/Del variant (rs66554220) with breast cancer (BC) and its clinical characteristics were analyzed in 182 women with non-familial BC and 221 disease-free women as a reference group. Both groups from western Mexico and sex–age-matched (sm-RG). The rs66554220 variant was amplified by SSP-PCR and the fragments were visualized in polyacrylamide gel electrophoresis. The variant rs66554220 was not associated with BC in our population. However, we suggest the Ins allele as a possible risk factor for developing BC at clinical stage IV (OR = 3.05, 95% CI = 1.16–7.96, p = 0.01); nevertheless, given the small stratified sample size (n = 11, statistical power = 41%), this is inconclusive. In conclusion, the 14-bp Ins/Del (rs66554220) variant of HLA-G is not associated with BC in the Mexican population, but might be related to advanced breast tumors. Further studies are required.
Databáze: Directory of Open Access Journals
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