Four New Limonoids from the Barks of Toona ciliata

Autor: Pan-Pan Zhang, Yun-Ge Bu, Shang Xue, Zhi-Rong Cui, Peng-Fei Tang, Jun Luo, Ling-Yi Kong
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Natural Products and Bioprospecting, Vol 11, Iss 1, Pp 81-86 (2020)
Druh dokumentu: article
ISSN: 2192-2195
2192-2209
DOI: 10.1007/s13659-020-00274-w
Popis: Abstract Four new limonoids, toonayunnanaes F − I (1 − 4), and six known compounds (5 − 10) were isolated from the barks of Toona ciliata. Their structures were elucidated by thoroughly analyzing of NMR and HRMS data, and single-crystal X-ray diffraction of 1. The oxetane ring moiety in 1 was rare in limonoids and other natural products. Compound 1 showed nitric oxide (NO) inhibitory effect with an IC50 38.45 ± 0.41 µM in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages. Graphic Abstract
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