Stem cell therapy in critical limb ischemia: Current scenario and future trends

Autor: Arun Sharma, Mumun Sinha, Niraj Nirmal Pandey, S H Chandrashekhara
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Indian Journal of Radiology and Imaging, Vol 29, Iss 04, Pp 397-403 (2019)
Druh dokumentu: article
ISSN: 0971-3026
1998-3808
DOI: 10.4103/ijri.IJRI_385_19
Popis: Critical limb ischemia (CLI) represents the most severe manifestation of peripheral arterial disease (PAD). It imposes a huge economic burden and is associated with high short-term mortality and adverse cardiovascular outcomes. Prompt recognition and early revascularization, surgical or endovascular, with the aim of improving the inline bloodflow to the ischemic limb, are currently the standard of care. However, this strategy may not always be feasible or effective; hence, evaluation of newer pharmacological or angiogenic therapies for alleviating the symptoms of this alarming condition is of utmost importance. Cell-based therapies have shown promise in smaller studies; however, large-scale studies, demonstrating definite survival benefits, are entailed to ascertain their role in the management of CLI.
Databáze: Directory of Open Access Journals
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