| Autor: |
Ekaterina Shatalina, Thomas S. Whitehurst, Ellis Chika Onwordi, Barnabas J. Gilbert, Gaia Rizzo, Alex Whittington, Ayla Mansur, Hideo Tsukada, Tiago Reis Marques, Sridhar Natesan, Eugenii A. Rabiner, Matthew B. Wall, Oliver D. Howes |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
EJNMMI Research, Vol 14, Iss 1, Pp 1-10 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2191-219X |
| DOI: |
10.1186/s13550-024-01099-1 |
| Popis: |
Abstract Background Mitochondrial function plays a key role in regulating neurotransmission and may contribute to general intelligence. Mitochondrial complex I (MC-I) is the largest enzyme of the respiratory chain. Recently, it has become possible to measure MC-I distribution in vivo, using a novel positron emission tomography tracer [18F]BCPP-EF, thus, we set out to investigate the association between MC-I distribution and measures of cognitive function in the living healthy brain. Results Analyses were performed in a voxel-wise manner and identified significant associations between [18F]BCPP-EF DVRCS−1 in the precentral gyrus and parietal lobes and WAIS-IV predicted IQ, WAIS-IV arithmetic and WAIS-IV symbol-digit substitution scores (voxel-wise Pearson’s correlation coefficients transformed to Z-scores, thresholded at Z = 2.3 family-wise cluster correction at p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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