The effect of streptozotocin-induced diabetes on the EDHF-type relaxation and cardiac function in rats
| Autor: | Mais Absi, Hani Oso, Marwan Khattab |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Journal of Advanced Research, Vol 4, Iss 4, Pp 375-383 (2013) |
| Druh dokumentu: | article |
| ISSN: | 2090-1232 2090-1224 |
| DOI: | 10.1016/j.jare.2012.07.005 |
| Popis: | The endothelium-derived hyperpolarizing factor (EDHF) response is a critical for the functioning of small blood vessels. We investigated the effect of streptozotocin-induced diabetes on the EDHF response and its possible role in the regulation of cardiac function. The vasorelaxant response to ACh- or NS309- (direct opener endothelial small- (SKCa)- and intermediate-conductance (IKCa) calcium-activated potassium channels; main components of EDHF response) were measured in pressurized mesenteric arteries (diameter 300–350 μm). The response to 1 μM ACh was reduced in diabetes (84.8 ± 2.8% control vs 22.5 ± 5.8% diabetics; n ⩾ 8; P |
| Databáze: | Directory of Open Access Journals |
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