Isotretinoin, Acne and Depression: A Prospective Controlled Study
| Autor: | Laura V. Langer, Lucas Prim, Thelma Skare, Virginia Wrublevski, Renato Nisihara |
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| Jazyk: | English<br />Portuguese |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Revista da Sociedade Portuguesa de Dermatologia e Venereologia, Vol 79, Iss 3 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2182-2395 2182-2409 74272926 |
| DOI: | 10.29021/spdv.79.3.1373 |
| Popis: | Introduction: Acne and isotretinoin, one of its treatment, have been linked to the occurrence of depression. Our aim was to study if isotretinoin is associated with depression in a sample of acne patients followed for 6 months comparing them with acne patients under other treatment modalities and control patients without acne. Methods: One hundred individuals were included: 50 controls and 50 with acne (24 using and 26 not using isotretinoin). Patients and controls answered the Beck Depression Inventory (BDI) and the 12 Item-Short Form Health Survey for quality of life (SF-12). Acne patients repeated this evaluation in 90 and 180 days. Results: No differences were found between controls and acne patients regarding BDI results but controls performed worse in the SF-12 mental domain (p=0.004). No differences were found within the acne group between those treated and not treated with isotretinoin in the comparison of the BDI and SF-12 (mental and physical domains) in days 0. 90 and 180 (all with p>0.05). Conclusion: In this small sample isotretinoin treatment showed to be safe regarding the occurrence of depression. |
| Databáze: | Directory of Open Access Journals |
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