| Autor: |
Kwon Young Lee, Hyo Young Jung, Dae Young Yoo, Woosuk Kim, Jong Whi Kim, Hyun Jung Kwon, Dae Won Kim, Yeo Sung Yoon, In Koo Hwang, Jung Hoon Choi |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Laboratory Animal Research, Vol 33, Iss 4, Pp 283-290 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
2233-7660 |
| DOI: |
10.5625/lar.2017.33.4.283 |
| Popis: |
Abstract In the present study, we examined the effects of Dendropanax morbifera Léveille leaf extract (DML) on dgalactose-induced morphological changes in microglia and cytokines, including pro-inflammatory cytokines (interleukin [IL]-1β, IL-6, and tumor necrosis factor [TNF]-α) and anti-inflammatory cytokines (IL-4 and IL-10) in the hippocampus. Administration of DML to d-galactose-treated mice significantly improved d-galactose-induced reduction in escape latency, swimming speed, and spatial preference for the target quadrant. In addition, administration of DML to d-galactose-treated mice significantly ameliorated the microglial activation and increases of IL-1β, IL-6, and TNF-α levels in the hippocampus. Administration of d-galactose significantly reduced IL-4 levels in the hippocampus, while administration of DML to d-galactose-treated mice significantly increased IL-4 level. However, we did not observe any significant changes in IL-10 levels in hippocampal homogenates. These results suggest that DML reduces d-galactose-induced mouse senescence by reducing pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α, as well as increasing anti-inflammatory cytokine IL-4. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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