| Autor: |
Ahmed Hasan Mohammed |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
European Journal of Biological Research, Vol 10, Iss 4 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2449-8955 |
| Popis: |
The elevated inflammatory cytokines suggest that a cytokine storm, also known as cytokine release syndrome (CRS), may play a major role in the pathology of pandemic Coronavirus Disease (COVID-19) leading to cause Acute respiratory distress syndrome (ARDS) and multiple organ dysfunction then death. However, there was a controversial efficacy of corticosteroids in the treatment of COVID-19 induced cytokine release syndrome (CRS). Novel therapies to treat COVID-19-induced CRS become urgent needed. One of the most common cytokine that showed to be critical in the COVID-19 is the IL-6 and this article discuss the pathogenesis of this cytokine in severe acute respiratory syndrome (SARS). Also, this article proposes to utilize interleukin-6 (IL-6) blockade and potential therapeutic effect of IFN-γ to manage COVID-19-induced CRS and discuss several factors that should be taken into consideration for its clinical application. DOI: http://dx.doi.org/10.5281/zenodo.4004241 |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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