Investigating the Unexpected Behavior for the Release Kinetics of Brilliant Blue Encapsulated into Calcium Alginate Beads
| Autor: | M. M. Elnashar, M. A. Yassin, A. El-Fetouh Abdel Moneim, E. M. Abdel Bary |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Eurasian Chemico-Technological Journal, Vol 12, Iss 1, Pp 69-77 (2011) |
| Druh dokumentu: | article |
| ISSN: | 1562-3920 2522-4867 |
| DOI: | 10.18321/ectj209 |
| Popis: | This work is focused on investigating the unexpected behavior for the release kinetics of brilliant blue (BB) encapsulated into calcium alginate beads. By increasing the alginate concentration from 1-3% (w/v), the release of BB over time was found to follow two different behaviors. For the first two hours, the order was 1% > 2% > 3%, after which it was as follow: 1% > 3% > 2%. The unanticipated increase in BB release using 3% (w/v) alginate beads after two hours over that of 2% (w/v) alginate was examined by the swelling and bursting tests. The results were showing clear evidences by data and image the unusual behavior of 3% (w/v) alginate beads at two hours of swelling. This unexpected behavior for the 3% (w/v) alginate beads might be due to the higher osmotic pressure inside the beads. Overall, 2% (w/v) calcium alginate beads were considered to be the optimum formulation showing an excellent carrier for targeting drugs to the intestine, where the swelling of the beads were 60 % in the acidic medium, it was 5000 % in the alkaline medium. |
| Databáze: | Directory of Open Access Journals |
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