Misfolded protein oligomers: mechanisms of formation, cytotoxic effects, and pharmacological approaches against protein misfolding diseases

Autor:	Dillon J. Rinauro, Fabrizio Chiti, Michele Vendruscolo, Ryan Limbocker
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Aggregation kinetics Secondary nucleation Protofibrils Lecanemab Cellular interactions Amyloid toxicity Neurology. Diseases of the nervous system RC346-429 Geriatrics RC952-954.6
Zdroj:	Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-32 (2024)
Druh dokumentu:	article
ISSN:	1750-1326
DOI:	10.1186/s13024-023-00651-2
Popis:	Abstract The conversion of native peptides and proteins into amyloid aggregates is a hallmark of over 50 human disorders, including Alzheimer’s and Parkinson’s diseases. Increasing evidence implicates misfolded protein oligomers produced during the amyloid formation process as the primary cytotoxic agents in many of these devastating conditions. In this review, we analyze the processes by which oligomers are formed, their structures, physicochemical properties, population dynamics, and the mechanisms of their cytotoxicity. We then focus on drug discovery strategies that target the formation of oligomers and their ability to disrupt cell physiology and trigger degenerative processes.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/fc5801f1b98b49f29a52e09a1075880f Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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