| Autor: |
Constantino Fernández, María Calvo, Natacha Leite, Andrés López, Tamara Ferreiro, Roi Ribera, Rocío Seijo, Ángel Alonso |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Nefrología (English Edition), Vol 37, Iss 6, Pp 638-645 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
2013-2514 |
| DOI: |
10.1016/j.nefroe.2017.11.003 |
| Popis: |
Desensitization is a procedure undergone by the recipient of a kidney transplant from a donor who is cross-match positive. The aim of this study was to present the outcomes from our hospital of kidney transplant recipients from HLA-incompatible live donors after desensitization.We studied 32 patients aged 46 ± 14 years with a mean fluorescence intensity (MFI) versus class I HLA of 7979 ± 4089 and 6825 ± 4182 MFI versus class II and relative intensity scale (RIS) of 8.9 ± 7.6. The complement-dependent cytotoxicity (CDC) cross-matching test was positive in 18 patients, flow cytometry was positive in 7 patients and donor-specific antibodies (DEA) were detected in 7. The protocol used was rituximab, plasmapheresis/immunoadsorption, immunoglobulins, tacrolimus, mycophenolic acid derivatives and prednisone.After 8 ± 3 sessions of plasmapheresis/immunoadsorption, 23 patients were transplanted (71.9%) and desensitization was ineffective in 9. There were baseline differences in MFI class I (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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