Hippocampus sparing volumetric modulated arc therapy in patients with loco-regionally advanced oropharyngeal cancer

Autor: Seung Won Seol, Brian H. Lee, Timothy L. Sita, Jay Ram Devineni, Tim J. Kruser, Sean Sachdev, Michelle Gentile, Irene Helenowski, Bharat B. Mittal, MD
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Physics and Imaging in Radiation Oncology, Vol 24, Iss , Pp 71-75 (2022)
Druh dokumentu: article
ISSN: 2405-6316
DOI: 10.1016/j.phro.2022.09.008
Popis: This study aimed to assess the incidental radiation exposure of the hippocampus (HC) in locoregionally-advanced oropharyngeal cancer patients undergoing volumetric modulated arc therapy and the feasibility of HC-sparing plan optimization. The initial plans were generated without dose-volume constraints to the HC and were compared with the HC-sparing plans. The incidental Dmean_median doses to the bilateral, ipsilateral and contralateral HC were 2.9, 3.1, and 2.5 Gy in the initial plans and 1.4, 1.6, and 1.3 Gy with HC-sparing. It was feasible to reduce the HC dose with HC-sparing plan optimization without compromising target coverage and/or dose constraints to other OARs.
Databáze: Directory of Open Access Journals