| Autor: |
Thomas M Scalea, Jonathan J Morrison, Philip J Wasicek, William A Teeter, Melanie R Hoehn, Shiming Yang, Hector Banchs, Samuel M Galvagno, Peter Hu, William B Gamble |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Trauma Surgery & Acute Care Open, Vol 4, Iss 1 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2397-5776 |
| DOI: |
10.1136/tsaco-2018-000194 |
| Popis: |
Background Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) increases cardiac-afterload and is used for patients in hemorrhagic shock. The cardiac tolerance of prolonged afterload augmentation in this context is unknown. The aim of this study is to quantify cardiac injury, if any, following 2, 3 and 4 hours of REBOA.Methods Anesthetized swine (70–90 kg) underwent a 40% controlled hemorrhage, followed by supraceliac resuscitative endovascular balloon occlusion of the aorta (REBOA) for 2 (n=5), 3 (n=5), and 4 hours (n=5). High-fidelity arterial wave form data were collected, and signal processing techniques were used to extract key inflection points. The adjusted augmentation index (AIx@75; augmentation pressure/pulse pressure, normalized for heart rate) was derived for use as a measure of aortic compliance (higher ratio = less compliance). Endpoints consisted of electrocardiographic, biochemical, and histologic markers of myocardial injury/ischemia. Regression modeling was used to assess the trend against time.Results All animals tolerated instrumentation, hemorrhage, and REBOA. The mean (±SD) systolic blood pressure (mm Hg) increased from 65±11 to 212±39 (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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