Several dominant clinical symptoms associated with Influenza A in Indonesia

Autor: Roselinda Roselinda, Nyoman Fitri
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Zdroj: Health Science Journal of Indonesia, Vol 2, Iss 2 Des, Pp 96-100 (2012)
Druh dokumentu: article
ISSN: 2087-7021
2338-3437
Popis: Latar belakang: Pada tahap awal infeksi, influenza A yang dapat menimbulkan pandemi, sangat sulit dibedakan dengan influenza-like illness (ILI) yang lain. Oleh karena itu gejala klinik sangat penting untuk mendiagnosis secara dini influenza A. Tujuan penelitian ini untuk mengidentifikasi gejala klinik dominan yang berkaitan dengan influenza A di Indonesia. Metode: Penelitian potong lintang. dilakukan di 20 puskesmas sentinel yang dipilih secara purposif di 19 propinsi di Indonesia tahun 2009. Data dan spesimen dikumpulkan oleh petugas paramedik atau medik puskesmas dari subjek rawat jalan dengan gejala ILI (batuk dan demam). Pemeriksaan Spesimen dilakukan di Pusat Rujukan Influenza Nasional di Jakarta. Penentuan Influenza A dengan real time RT-PCR. Hasil: Sebanyak 1802 subjek berdata lengkap untuk analisis influenza A dari 2728 subjek dengan gejala ILI, dan 23,1% (416 subjek) didiagnosis positif influenza A. Pada model terakhir terungkap bahwa subjek dengan pilek dibandingkan dengan yang tidak pilek berisiko 3,6 kali lipat Influenza A [risiko relatif suaian (RRa) = 3,59; 95% interval kepercayaan (CI) = 1,34-9,63]. Subjek dengan nyeri tenggorok dibandingkan dengan yang tanpa nyeri tenggorok berisiko 54% lebih besar menderita Influenza A (RRa = 1,54; 95% CI = 0,95-2,58; P = 0.082). Seangkan, subjek dengan riwayat demam dibandingkan tanpa riwayat pernah demam dalam dua hari terakhir berisiko 42% lebih besar menderita Influenza A (RRa = 1,42; 95% CI = 0,97-2.,7; P = 0,069).Kesimpulan: Selain demam dan batuk, keluhan pilek dan nyeri tenggorok, serta riwayat pernah demam dalam dua hari terakhir merupakan faktor risiko dominan yang berhubungan dengan Influenza A. (Health Science Indones 2011;2:96-100).Abstract Background: Influenza A has a potential to become a pandemic, in the early stages is difficult to differentiate influenza to influenza-like illnesses. Therefore, the dominant clinical symptoms are the important keys to predict influenza A infection in patients with influenza-like illnesses (ILI). The aim of this study is to identify additional dominant symptoms associated to influenza A in Indonesia.Methods: The eligible subjects of this study were outpatient who had ILI symptom, i.e. who had fever (38o or more) and coughing in purposive selected 20 Health Centers in 19 provinces of Indonesia during year 2009. Paramedics and medical staff identified the ILI cases and collected specimens. Laboratory tests for RT-PCR were performed at the National Influenza Center in Jakarta.Results: Of 2728 specimens, 1802 had complete data for this analysis, and 23.1% (416 subjects) diagnosed positive influenza A. Those who had than did not have runny nose symptom had 3.6-fold risk of influenza A [adjusted relative risk (RRa) = 3.59; 95% confidence interval (CI) = 1.34-9.63). In term of sore throat, those who had than did not have it had 54% more risk of influenza A (RRa = 1.54; 95% CI = 0.95-2.58; P = 0.082). Furthermore, those who ever had than did not have fever for the last two days had 42% more risk of influenza A (RRa = 1.42; 95% CI = 0.97-2.07; 0,069).Conclusion: In addition to fever and coughing, runny nose, sore throat, and ever had fever are dominantly associated with influenza A. (Health Science Indones 2011;2:96-100)
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